We invest in Tough Tech Founders.
Engine Ventures is a venture capital firm investing the next generation of Tough Tech founders—providing capital, operational expertise, and access to a powerful network across academia, industry, and government. We help build and scale companies unlocking massive opportunities in energy and climate, human health, advanced systems, and infrastructure.
Building a stronger energy future takes innovation across industrial systems, materials, and infrastructure. These companies are driving practical solutions that boost resilience, reduce environmental impact, and power long-term economic growth.
Transformative solutions are emerging across medicine, health and disease monitoring, and food systems. Expanding their applications and access drives our companies, as they converge biology, materials, engineering, and AI to empower a healthy, vibrant world.
We invest in the development and integration of complex systems and technologies—from advanced computing to mobility to the built environment—that enable more effective, productive, and inclusive foundations for industrial innovation.
- 1/4 of all greenhouse gas emissions are from energy production.
- Safe, unlimited, carbon-free fusion power.
- Lack of cures for common diseases.
- Curing the world’s toughest diseases by automating personalized medicine.
- Artificial intelligence is limited by computing power.
- Processing with photons instead of electrons.
- Unidentified public health problems.
- Sewage analysis to protect cities.
- Industrial thermal separations account for 12% of all U.S. energy consumption.
- Decarbonizing every industrial process.
- Vaccines are hard to transport and not maximally effective.
- A shelf-stable patch with better delivery capability.
- A third of global food produced is wasted.
- A natural coating to reduces spoilage and packaging waste.
- A 100% renewable grid requires on-demand energy access.
- 100% renewable grid with multi-day energy storage systems.
- Instability of food supply chains.
- Producing low-carb, protein-rich fungi flour.
- Supply chain gaps from a truck driver shortage.
- Self-driving trucks at warehouses and factories.
- Deforestation.
- Laboratory-derived wood products.
- Cloud computing is massively inefficient.
- Eliminate guesswork to optimize infrastructure.
Energy & Climate
“Imagine the world in 2050. Our vision is for 10,000 zero carbon ARC fusion power plants delivering electricity to the grid globally, meeting greater than 20% of humanity’s demand.”
Bob Mumgaard CEO & Founder, Commonwealth Fusion Systems
Human Health
“Cellino brings a truly unique approach, with a high level of complexity: hardware, AI/ML, bioengineering, cell based therapy, automation, and fluidics. Our multidisciplinary team comes together actively, solving problems with creativity.”
Nabiha Saklayen CEO & Founder, Cellino
Advanced Systems & Infrastructure
“We are at the beginning of an unprecedented journey toward the next generation of AI which will transform our way of life. Generative AI and Recommendation Engines have already begun to measurably impact business processes, products and services. The next wave of data center infrastructure is being architected to deliver tremendous efficiency in AI workload by disaggregation of memory and compute resources which is enabled by optical interconnectivity. Our technology solutions are lighting the way to the future of accelerated computing.”
Dave Lazovsky CEO & Co-Founder, Celestial AI